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Fig. 6 | Molecular Brain

Fig. 6

From: Rapid and stable changes in maturation-related phenotypes of the adult hippocampal neurons by electroconvulsive treatment

Fig. 6

Long-lasting phenotypic change in GCs after repeated ECS. a, b, The relative expression of Calb1 and Tdo2 at indicated time intervals after single (a) or repeated (b) ECS (a, Tukey’s test following one-way ANOVA: F (2,9) = 54.21, *** P < 0.001 for Calb1, F (2,9) = 1048, *** P < 0.001 for Tdo2, b, F (4,15) = 123, *** P < 0.001 for Calb1, F (4,15) = 53.67, *** P < 0.001 for Tdo2). c, Frequency facilitation tested at various time intervals after three or 11 times of ECS. d, The relative expression of Calb1 was compared between 5-HT4R-KO (-/-) mice and wild-type (+/+) mice at 14 days after 11 times of ECS (*** P < 0.001, Bonferroni’s post hoc test following two-way ANOVA). e, The effect of X-ray (10 Gy) on the reduction of Calb1 at 14 days after 11 times of ECS. (** P < 0.01, Bonferroni’s post hoc test following two-way ANOVA). f, Representative images of immunoreactivity for doublecortin in non-irradiated (ECS × 11) or irradiated (X-ray-ECS × 11) mice at 14 days after 11 times of ECS. Scale bar: 200 μm. The number (n) is shown in the graph. Data are presented as means ± SEM

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