Fig. 1

KA receptor-mediated EPSCs in adult ACC pyramidal neurons. a Diagram showing the placement of stimulating and recording electrodes in the ACC. b Control EPSCs were recorded in the presence of picrotoxin (PTX, 100 μM) and AP-5 (50 μM). After the perfusion of GYKI 53655 (100 μM), a small residual current remained, which could be totally blocked by CNQX (20 μM). In the following example of EPSCs, each trace represents an average of 5–10 consecutive recordings. c Sample points showing the time course of GYKI 53655 and CNQX effects on the neuron shown in b. d Statistical results showing the percentage of EPSCs in the presence of SYM 2206, GYKI 53655 or CNQX. Modified from Wu et al. [3]