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Fig. 3 | Molecular Brain

Fig. 3

From: ApoE isoforms differentially regulates cleavage and secretion of BDNF

Fig. 3

ApoE4 inhibits the expression of intracellular prepro-BDNF. Primary human astrocytes were treated with cholesterol (Chol; 100 μM), with or without ApoE2 (20 nM) or ApoE3 (20 nM) or ApoE4 (20 nM) for 24 h. a Immunoblot showing expression levels of BDNF in the cell lysate after 24 h. ‘M’ indicates molecular weight marker. b ApoE2 + cholesterol induces while ApoE4 + cholesterol inhibits BDNF synthesis. Data are represented as mean ± SE of three independent experiments (*p < .05; **p < .05; ***p < .005; one-way ANOVA, post hoc Newman-Keuls multiple comparison test)

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