Skip to main content

Table 1 Overview of pharmacological microglia depletion studies

From: An updated assessment of microglia depletion: current concepts and future directions

Pharmacological intervention

Efficiency

Time window

Physiological effects

References

CSF-1R inhibitor (PLX3397)

99%

21 days

has no cognitive or behavioral impairments

[63]

CSF-1R inhibitor (PLX3397)

~90%

21 days

promotes brain recovery in intracerebral hemorrhage

[66]

CSF-1R inhibitor (PLX3397)

~90%

21 days

exacerbates brain recovery in brain ischemia

[69]

CSF-1R inhibitor (PLX3397)

97%

21 days

increases infarct size and brain injury after stroke

[67]

CSF-1R inhibitor (PLX5622)

~90%

2 or 6 weeks

ameliorates radiation-induced cognitive deficits

[70]

CSF-1R inhibitor (PLX5622)

~90%

7 days

ameliorates inflammation induced by neuronal lesion

[64]

CSF-1R inhibitor (PLX5622)

~80%

28 days

prevents neuronal loss and contextual memory in Alzheimer’s

[65]

CSF-1R inhibitor (GW2580)

Not shown

6 weeks

attenuates depression-like behavior and kidney function

[71]

Liposomal clodronate

70%

2 weeks

decreases anxiety and despair behaviors throughout life

[76]

Liposomal clodronate

~80%

1 or 5 days

alters spatial learning performance and social behavior

[75]

Mac-1-saporin

50%

1 day

triggers bone marrow derived-cell infiltration into spinal cord

[68]