An updated assessment of microglia depletion: current concepts and future directions

Table 2 Overview of genetic microglia depletion studies

Depletion strategy	Efficiency	Time window	Physiological effects	References
CD11b-HSVTK	56%	7 days	little effect on axonal degeneration in concussive brain injury	[80]
CD11b-HSVTK	>90%	7 days	represses EAE-associated neuroinflammation	[81]
CD11b-HSVTK	>90%	2 weeks	circulating monocytes occupy brain after microglia depletion	[79]
CD11b-HSVTK^mt-30	51%	30 days	has no effect on motor neuron degeneration in ALS	[82]
CX3CR1^CRE DTR	80%	3 days	causes a cytokine storm and astrogliosis	[85]
CX3CR1^CRE DTR	99%	1 day	reduces synaptic structural plasticity associated with learning	[84]

ISSN: 1756-6606