Fig. 1
From: Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice
In vivo recording in CA1 demonstrates alterations in hippocampal rhythmic oscillations and firing rates in Nf1 +/− mice. a The timeline of the in vivo recording experiments. The typical local field potentials (LFPs) recordings and unit spikes in CA1, the diagram of mice in recording with 16-channel microelectrode array were shown. b Histograms show the averaged power spectral density of the neuronal rhythmic oscillations (theta). Data are expressed as mean ± SEM (WT, n = 5; Nf1 +/−, n = 5). Two-way analysis of variance with repeated measures and post hoc Bonferroni tests was used to evaluate differences in local field potential power spectrum density in day and night recordings in Nf1 +/− and WT groups. *** p < 0.001. c The differences in the spike waveforms of hippocampal pyramidal neurons between day and night in WT and Nf1 +/− groups (WT, N = 5, nday = 38, nnight = 37; Nf1 +/−, N = 5, nday = 31, nnight = 25). d The spike firing rates of pyramidal cells. Comparison of the firing rates of pyramidal cells during day and night recordings (WT, N = 5, nday = 38, nnight = 37; Nf1 +/−, N = 5, nday = 31, nnight = 25). Paired t-test was used to evaluate differences in firing rates of pyramidal cells. **p < 0.01, ***p < 0.001