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Fig. 7 | Molecular Brain

Fig. 7

From: O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease

Fig. 7

Thiamet G increases and rapamycin decreases AKT phosphorylation. DIV7 primary rat cortical neurons were exposed to rapamycin (1 μM) and/or TG (0.25 μM) for 7 d. Inhibition of OGA (7 d) increased p-AKT (S473) and inhibition of MTOR decreased p-AKT, as shown by the western blot analyses. β-actin was used as a loading control. Quantification of western blot band intensities was performed using NIH image J. Data = mean ± SEM (n = 3), *p < 0.05 compared to no TG, #p < 0.05 compared to –rapamycin. Results were analyzed by ANOVA followed by Bonferroni’s Multiple Comparison post-hoc test

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