Fig. 3

Intraperitoneal injection of O-1602 reverses forced swimming-induced anxiety-like behavior. a In the EPM, administration of O-1602 increased the number of entries in the open arms and the time into the open arms did not change significantly as compared to the vehicle group. CID16020046 and O-1602 decreased the frequency in the open arms and had no significant changes on the duration in the open arms as compared to the O-1602 group. *p < 0.05, **p < 0.01 versus control group; ^## p < 0.01 versus vehicle group; ^&& p < 0.01 versus O-1602 group. b In the OFT, administration of O-1602 significantly increased the time spent in the central area and had no effect on the total distance traveled. CID16020046 and O-1602 treatment decreased the time spent in the central area, while it had no significant effect on the total distance traveled. *p < 0.05 versus control group; ^## p < 0.01 vehicle group; ^&& p < 0.01 versus O-1602 group. c Administration of O-1602 reversed stress-induced expression of GluA1 and GluN2A, but not GluN2B. CID16020046 and O-1602 treatment abolished O-1602-mediated decrease in GluA1 and GluN2A expression, while had no effect on the expression of GluN2B. **p < 0.01 versus control group; ^## p < 0.01 versus vehicle group; && p < 0.01 versus O-1602 group. Each group contains 6–8 mice. Data are from three independent experiments