Fig. 2

Reduced infarct volume in mGlu2^−/− mice subjected to transient MCAO. Evans blue perfusion showing the absence of anatomical abnormalities of the MCA mGlu2^−/− with respect to mGlu2^+/+ mice (a, b). No difference in the reduction of cerebral blood flow in response to MCAO was found among mGlu2^+/+ and mGlu2^−/− mice. Nissl staining of mGlu2^+/+ and mGlu2^−/− mouse brains after transient MCAO. Mice were killed 48 h after reperfusion (c). Values of infarct volume (d) are means ± S.E.M. (n = 9 per group). ⁺ p < 0.05 (Student’s t-test; t₁₆ = 1.75)