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Fig. 3 | Molecular Brain

Fig. 3

From: Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia

Fig. 3

Improved short-term behavioral outcome in mGlu2−/− mice subjected to transient MCAO. Neurological deficit in mGlu2+/+ and mGlu2−/− mice subjected to transient MCAO (a). Bars are means + S.E.M. Friedman nonparametric ANOVA revealed significant effect of Time for mGlu2+/+ mice [Chi Sqr.(N=7, df=4) = 23.46, p = 0.0001] and for mGlu2−/− mice [Chi Sqr.(N=9, df=4) = 31.62, p = 0.000001]; () and (O) are Wilcoxon matched pairs comparisons between T0 (before ischemia) and 2, 24 and 48 h for mGlu2+/+ mice (n = 9) and mGlu2−/− mice (n = 11), respectively; + Kruskal-Wallis ANOVA and post-hoc Kruskal-Wallis test by ranks for difference between mGlu2+/+ and mGlu2−/− mice. Grip strength of ipsilateral and contralateral FL in mGlu2+/+ and mGlu2−/− mice subjected to transient MCAO (b). MCAO resulted into a significant reduction in muscular strength in both, ipsilateral and contralateral FLs, after ischemia compared to T0 in mGlu2+/+ (n = 7) and mGlu2−/− mice (n = 8) (p < 0.05, Dunnett’s t test). Three-way ANOVA for repeated measures (first factor GROUP with two levels: mGlu2+/+ and mGlu2−/− mice, second repeated measure factor SIDE with two levels: ipsilateral FL and contralateral FL, and third repeated measure factor TIME with four levels: T0, 2, 24, and 48 h) revealed significant effects of GROUP (F1,9 = 7.11, p = 0.026), SIDE (F1,9 = 6.69, p = 0.029), TIME (F3,27 = 21.16, p = 0.0000001), interactions SIDE x TIME (F3,27 = 3.83, p = 0.021) and GROUP x SIDE x TIME (F3,27 = 4.59, p = 0.01). & Comparisons between ipsilateral and contralateral FL in mGlu2+/+ mice (Fisher LSD test). + Comparisons between mGlu2+/+ and mGlu2−/− mice for the contralateral FL (Fisher LSD test)

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