Fig. 7
Seizure-like activity was partially reversed by the GABAB antagonist CGP46381 (100 μM). a In the left panel, cortical and thalamic seizure-like activity was induced by electrical stimulation of the corpus callosum (yellow bar) after applying 4-AP. In the middle panel, corpus callosum stimulation-induced seizure-like activity was suppressed by 10 s light stimulation (blue mark) after corpus callosum stimulation. In the right panel, seizure-like activity was partially reversed by the GABAB antagonist CGP46381 (100 μM). b Average discharges induced by different light stimulation conditions and drug applications in the S1 region (left panel) and thalamus (right panel). The suppressive effects of 10 s light stimulation were reversed by the GABAB antagonist. p < 0.05, one-way ANOVA with repeated test followed by post hoc test. n = 3