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Fig. 4 | Molecular Brain

Fig. 4

From: The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila

Fig. 4

Altered Moesin expression disrupts dendritic arborization. Immunohistochemistry with anti-GFP (green) antibody on whole mount brains. All images are confocal projections through the optic lobe of the brain. a, b. 3A–GAL4 > Lifeact labels the dendritic arbor of the six neurons comprising the vertical system of LPTCs. c, d. Knockdown of Moesin results in defects in dendritic branching; arrows show stunted growth of VS branches. eg. Overexpression of Moesin disrupts dendritic branching; arrow points to stunted VS branch. Anti-Myc staining (magenta) reveals that it localizes to the primary branches of the vertical system. ik. Myc-MoeT559D distributes throughout the VS neurons, including the branchlets and spines. l. Expression of Myc-MoeT559D results in increased Lifeact staining the VS1 branch in comparison to expression of Myc-Moe (h)

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