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Fig. 6 | Molecular Brain

Fig. 6

From: Role of GABAA receptors in alcohol use disorders suggested by chronic intermittent ethanol (CIE) rodent model

Fig. 6

Two-Bottle Choice Assessment of EtOH Drinking by GABAAR Wild Type and α2KO and α4KO Mice. a. EtOH preference assayed by voluntary access to EtOH (15%) in the 2 BC. (Δ, WT [C57/BL/6]; Ο, α4KO (G Homanics); and ם, α2KO (U Rudolph), n = 6–8). After the 3rd week, the EtOH intake in the α4KO group became significantly higher than that in the WT group. In contrast, the α2KO group did not show EtOH preference. b. Anxiety assay after 3 weeks of 2 BC measured by EPM (n = 6 ~ 8). The α4KO EPM data show reduced anxiety relative to wild type, while the α2KO exhibit more anxiety

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