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Table 1 The composition of CS disaccharides in T1KO compared with WT

From: Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis

mol% Average SEM Average SEM P value
Cerebrum WT KO  
 O 9.1 0.19 12.0 1.04 0.046
 C 1.8 0.27 5.3 0.12 0.821
 A 87.2 0.14 77.7 0.69 0.027
 D 0.7 0.05 2.1 0.03 0.003
 E 1.2 0.05 2.9 0.44 0.001
 Total 100.0   100.0   
Diencephalon WT KO  
 O 4.4 0.17 4.7 0.25 0.374
 C 3.8 0.09 3.0 0.06 0.002
 A 88.9 0.34 89.4 0.34 0.367
 D 1.3 0.13 1.0 0.03 0.075
 E 1.6 0.05 1.9 0.06 0.030
 Total 100.0   100.0   
Cerebellum WT KO  
 O 7.6 1.88 4.5 0.24 0.183
 C 3.7 0.17 4.9 0.43 0.062
 A 85.5 1.52 87.3 0.46 0.333
 D 1.8 0.20 1.6 0.12 0.395
 E 1.4 0.01 1.7 0.15 0.082
 Total 100.0   100.0   
Spinal Cord WT KO  
 O 12.0 1.04 11.8 2.68 0.930
 C 5.3 0.12 4.7 0.06 0.041
 A 77.7 0.69 78.7 2.27 0.647
 D 2.1 0.03 1.4 0.25 0.036
 E 2.9 0.44 3.4 0.59 0.525
 Total 100.0   100.0   
Visual Cortex WT KO  
 O 9.0 0.18 10.7 0.16 4E-04
 C 2.7 0.01 2.3 0.03 3E-05
 A 86.4 0.18 84.6 0.19 5E-04
 D 0.7 0.03 0.4 0.03 4E-04
 E 1.2 0.01 1.9 0.03 5E-07
 Total 100.0   100.0   
  1. Note that among the five patterns of CS-derived disaccharides, CS-E in T1KO was significantly increased in each brain region. Statistically significant differences in T1KO are shown in italics (p < 0.05), compared to the corresponding results for WT [7, 8, 10]
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