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Fig. 3 | Molecular Brain

Fig. 3

From: Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage

Fig. 3

TsI treatment immediately after HIBD alleviates spatial learning and memory deficits in neonatal HIBD rats. a The flowchart illustrates the experimental protocols of TsI treatments and water maze test. Rats received TsI treatment (5 mg/kg per day, i.p.) seven times after HIBD model established, and the first treatment of TsI was conducted immediately after HIBD. The Morris water maze test was performed from postnatal day 35 to 42 (P35–42). b The average escape latency to the hidden platform location is plotted for each spatial learning day in the Morris water maze task. c-e Bar graph showed the time spent in the hidden platform-located quadrant c, the latency of first time to the hidden platform location (d) and the number of entries into the platform zone (e) during the probe test with absence of the hidden platform, which is conducted 24 h after the last learning trial. Data was expressed as mean ± SEM. *p < 0.05, **p < 0.01

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