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Fig. 3 | Molecular Brain

Fig. 3

From: Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors

Fig. 3

Overexpression of PKMζ augments the size of large-amplitude miniature excitatory postsynaptic currents (mEPSCs). a The mEPSC frequency of neurons expressing PKMζ K98W, PKMζ T227E, or control neurons at DIV 16–17 (One-way ANOVA, p = 0.1697, n = 20–21 neurons). b The mean mEPSC amplitude of neurons expressing PKMζ K98W, PKMζ T227E, or control neurons at DIV 16–17 (One-way ANOVA, p = 0.1483). c The amplitude of 8 largest mEPSCs from each cell (PKMζ K98W, n = 20 neurons, n = 160 events; Control, n = 20 neurons, n = 160 events; PKMζ T227E, n = 21 neurons, n = 168 events; One-way ANOVA with post-hoc Newman Keuls multiple comparison test (**p < 0.01, ***p < 0.001)). Data are represented as mean ± S.E.M.

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