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Fig. 6 | Molecular Brain

Fig. 6

From: Characterization of excitatory synaptic transmission in the anterior cingulate cortex of adult tree shrew

Fig. 6

The evoked presynaptic glutamate release was decreased in the tree shrew. a Representative traces of paired-pulse ratio recorded at interval of 50 ms in tree shrew and mouse. b Statistical results showed that the paired-pulse ratio increased in tree shrew (n = 27 neurons/6 tree shrews) compared with mouse (n = 22 neurons/6 mice). c Representative traces of NMDA receptor mediated EPSCs at 0, 5, and 20 min in the presence of MK-801 (35 μM) in tree shrew and mouse neurons with a membrane holding at −20 mV or −30 mV. d Plot of time course of MK-801 blockade of NMDA receptor mediated EPSCs in tree shrew (red, n = 8 neurons/3 tree shrews) and mouse (black, n = 8 neurons/3 mice). e Individual and statistical data showed the decay time required for the peak amplitude of NMDA receptor mediated EPSCs to decrease to 50% of initial value in the presence of MK-801. Significantly faster time was observed in mouse than tree shrew. *P < 0.05, ***P < 0.001, error bars indicated SEM

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