Fig. 5

Erasure test. Memory was tested 9 days after virus injection (day 16), a time at which virally mediated protein expression had ended (Fig. 1b). a Superposition of paths of six rats (top). Memory is largely preserved after GFP expression but was largely erased (bottom) after expression of dominant-negative CaMKII (K42 M). b,c Summary data. A two-sample K-S test was used to determine statistical significance (p = 0.012, D = 0.83; n = 6). The differences on trials 1 and 7 (pre viral injection) between K42 M and GFP were not statistically significant (p = 0.81 and D = 0.33 for trial 1; p = 0.32 and D = 0.5 for trial 7). Error bars represent mean ± SEM. Asterisks indicate statistical significance (p < 0.05; Kolmogorov–Smirnov test). Reproduced with permission from [48]