Fig. 1
From: Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
PKRi treatment rescues fear memory deficit in 5XFAD mice. Eleven to twelve months old 5XFAD mice showed significant deficit in contextual fear memory, which was rescued by PKRi treatment (0.335 mg/kg) (% freezing: WT, 49.03 ± 6.67%, n = 9 mice; WT + PKRi, 46.78 ± 5.90%, n = 10 mice; 5XFAD, 8.74 ± 4.18%, n = 6 mice; 5XFAD + PKRi, 35.55 ± 10.38%, n = 7 mice; Two-way ANOVA, interaction between genotype and PKRi, p = 0.0558, Bonferroni post-tests, *p < 0.05, **p < 0.01). Bars represent as mean ± SEM