Fig. 3

Decreased expression of GluR1 and a nominally significant decrease in SV2 expression in the middle molecular layer of the DG of Shn2 KO mice. (a–c) Representative images of SV2 (a), GluR1 (b), and PSD95 (c) staining in the DG of WT and Shn2 KO mice. Bar graphs represent fluorescence intensity normalized to that in the middle molecular layer in the DG of WT mice, and are presented as the mean ± SEM. For WT, n = 4 mice; for Shn2 KO, n = 4 mice. The P-values were calculated using Student’s t-test. Scale bar, 300 μm; g, granule cell layer; h, hilus; m, molecular layer