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Fig. 4 | Molecular Brain

Fig. 4

From: Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory

Fig. 4

Inhibition of calpain blocks c-fos induction in the hippocampal CA1 and CA3 regions when memory is consolidated. a Effects of a systemic injection of a low- or high-dose of ALLN immediately after the training on LTM (VEH, n = 13; ALLN 30 mg/kg, n = 8; ALLN 70 mg/kg, n = 9). *p < 0.05, compared with the VEH group at the test. b Experimental design for IHC. c Representative immunohistochemical staining of c-fos-positive cells in the CA1, CA3, and DG regions of the indicated groups. Scale bar, 50 μm. d The number of c-fos-positive cells in the CA1, CA3, and DG regions of no-shock/VEH, no-shock/ALLN, shock/VEH, and shock/ALLN groups (n = 9 for each group). *p < 0.05, compared with the other groups. Error bars indicate SEM

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Molecular Brain

ISSN: 1756-6606