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Fig. 6 | Molecular Brain

Fig. 6

From: Genetic dissection of the neuro-glio-vascular machinery in the adult brain

Fig. 6

Depletion of astrocytes decreases the survival of adult-generated dentate granule neurons. a Experimental timeline in which iDTR mice are first injected with intravenous CAV2-Cre to induce iDTR expression in targeted cells, then treated with intraperitoneal DT to deplete DTR+ cells. b Representative images of DCX staining in the dentate gyrus from saline- and DT-treated iDTR mice. The scale bar is 100 μm. On the right is a plot of DCX+ cell density in the GCL of DT and saline treated iDTR mice. Two-tailed, unpaired t-test, P = 0.0006. c Representative images of Nestin + cells in the SGZ of iDTR mice treated with saline or DT. On the right is a plot of the density of Nestin + cells in the SGZ. Two-tailed unpaired t-test, P = 0.776. The scale bar is 10 μm. d Plot of Ki67+ cells per dentate gyrus of saline- and DT-treated iDTR mice. Two-tailed unpaired t-test P = 0.488. Data are plotted as mean +/− SEM. * indicates P < 0.05, ** indicates P < 0.01. n = 4 animals per condition

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