Fig. 3
From: Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro
Pro-inflammatory CKs modulation of GABAA receptor-mediated event time course is prevented by MT2. Representative traces of IPSC recorded from organotypic spinal slices prior and after CKs treatments in control (a) and in the presence of MT2 (b). Note that while CKs did not increase IPSC frequency, they affected IPSC time course (superimposed tracings). c Box-plots summarize the decay time constant values in all conditions, in the insets the scaled and superimposed average IPSC are depicted (control in black, CKs 4H in red and 6H in blue) in the absence or in the presence of MT2. Note that in the presence of MT2 no changes in the IPSC time course were detected following CKs treatments. In the inset: the τ is expressed as % in respect to each control group, note the reduction by 24.59% in CKs4H and by 32.48% in CKs6H. Virtually no decreases were observed in MT2: slight increase by 1.12% in CKs4H + MT2 and slight reduction by 2.44% CKs6H + MT2. See the Additional file 2: Figure S2 for GABAergic PSCs in the absence or in the presence of MT2