Fig. 4

Effects of intracerebroventricular injection of the selective GHSR1a antagonist [D-Lys3]-GHRP-6 on motor coordination. a Average latency to fall in the rotarod test. ^**p < 0.01 vs. SAL. b Time-course change in the locomotor-enhancing effect of morphine (5 mg/kg, s.c.) after treatment with [D-Lys3]-GHRP-6 at 0.3 nmol (n = 7) or saline (n = 8). Each point represents the mean activity distance for 1 min with SEM. c Total locomotor activity induced by morphine (5 mg/kg, s.c.) after treatment with [D-Lys3]-GHRP-6 at 0.3 nmol (n = 7) or saline (n = 8). Each column represents the mean total activity distance for 120 min with SEM. ^*p < 0.05 vs. SAL-MRP5