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Fig. 5 | Molecular Brain

Fig. 5

From: Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

Fig. 5

Effects of intra-SNc injection of [D-Lys3]-GHRP-6 on motor coordination. a Microinjection sites of [D-Lys3]-GHRP-6 in the SNc. Plates show coronal sections of the mouse brain. b Schedule for the experiment. c Accelerated rotarod test (4-20 rpm). The line graph shows the average latency to fall in the rotarod test for 15 min after bilateral microinjection of [D-Lys3]-GHRP-6 (1, 2.5 or 5 nmol / each site) or saline (n = 6/group) into the SNc. *p < 0.05 vs. Saline. d-e The balance beam test was performed 10 min after the microinjection of [D-Lys3]-GHRP-6 (1, 2.5 or 5 nmol / each site) or saline (n = 6/group) into the SNc. ***p < 0.001 vs. Saline

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