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Fig. 1 | Molecular Brain

Fig. 1

From: Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats

Fig. 1

Endogenous production of RvD2 and effects of exogenous RvD2 treatment on brain I/R injury. a The level of the endogenous RvD2 after MCAO/R in brain tissue was detected by ELISA at 12, 24, 48, 72, and 96 h. b and c IL-6 and TNF-α secretions were determined by ELISA after different doses of RvD2 treatment for MCAO/R in brain tissue. d TTC-stained coronal sections from representative animals at 72 h after reperfusion. The infarct volumes and reproducible infarct volumes were observed. e The infarct volume was expressed as a percentage of the ipsilateral hemispheric volume. f The neurobehavioral score was shown as the median, with interquartile range. g Brain water content was detected. h The protein levels of albumin were detected by Western blot, and the mean value of the sham group was normalized to 1.0. In (ac, eh), data are means ± SEM. *P < 0.05, **P < 0.01 vs. sham group; &P < 0.05, &&P < 0.01, N.S. = no significant differences, n = 6

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