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Fig. 3 | Molecular Brain

Fig. 3

From: Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats

Fig. 3

RvD2 exerted rescue effects on MCAO/R-induced neuron and BMVEC death. Apoptotic cell death was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. Sections were labeled by TUNEL (green) to detect apoptotic neurons (red) (a) and brain microvascular endothelial cells (BMVECs) (red) (c) and counterstained with DAPI (blue) to detect nuclei. Arrows point to TUNEL-positive cells. The percentage of TUNEL-positive brain cells was calculated (b and d). Scale bar = 64 μm (A) and 24 μm (c). Data are expressed as mean ± SEM, n = 6. **P < 0.01 vs. sham group, &P < 0.05, N.S. = no significant differences. e Fluoro-Jade B (FJB) staining was used to detect necrosis. Scale bar = 64 μm. The number of FJB-positive brain cells was calculated (f). Data are expressed as mean ± SEM, n = 6. **P < 0.01 vs. sham group, &P < 0.05, N.S. = no significant differences

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