Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

Table 1 Peptides used in study

Peptide	Sequence^a	Arginine/AA residues	% Arginine residues	Net charge
R18	H-RRRRRRRRRRRRRRRRRR-OH	18/18	100	+ 18
R18D	H-rrrrrrrrrrrrrrrrrr-OH	18/18	100	+ 18
JNKD	H-tdqsrpvqpflnlttprkprpp-rrrqrrkkrg-NH₂	9/32	28	+ 12

^aAt the N-terminus, H indicates free amine. At the C-terminus, OH indicates free acid, and NH₂ indicates amide. AA = amino acids. Lowercase single letter code indicates D-isoform of the amino acid. JNKD = JNKI-1-TATD

ISSN: 1756-6606