Fig. 2

Latency to fall in the rotarod test. Motor coordination was assessed in 16- (a) and 20-weeks (b) wt or R6/1 old mice using the rotarod test. Mice of indicated genotypes and ages were exposed chronically to vehicle or repaglinide. The number of mice used: wt-DMSO (35), wt-RP (20), R6/1-DMSO (30), R6/1-RP (24). Data are shown as mean ± SEM. Nonparametric ANOVA, Kruskal-Wallis test (P values for both panels < 0.0001) with Dunn’s multiple comparisons between selected groups was used. **** p < 0.0001 vs wt-DMSO; # p < 0.05 R6/1-RP vs R6/1-DMSO