Fig. 3

Induced DREAM haplodeficiency delays onset of cognitive impairment in R6/1 mice. Memory was assessed in 16- (a) and 20-weeks (b) old mice using the novel object recognition test. The number of mice used: wt (21), R6/1 (20–23), DREAM^+/− (9–12), R6/1× DREAM^+/− (9–12). DREAM haplodeficiency is indicated as D^+/−. Data are shown as mean ± SEM. Non-parametric ANOVA, Kruskal-Wallis test (P values: a) 0.0262 and 0.0002 for 4 and 24 h, respectively; b) 0.0122 and 0.0187 for 4 and 24 h, respectively) with Dunn’s multiple comparisons between selected groups were used. *** p <0.005, ** p <0.01, R6/1 vs wt, ### p <0.005, R6/1xDR^+/− vs R6/1xD^+/+