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Fig. 4 | Molecular Brain

Fig. 4

From: Inhibition of DREAM-ATF6 interaction delays onset of cognition deficit in a mouse model of Huntington’s disease

Fig. 4

Repaglinide activates ATF6 processing in mouse hippocampal neurons. Western blot analysis of whole cell extracts from hippocampus of wild-type and R6/1 mice receiving DMSO or repaglinide. A representative blot is shown. Bands corresponding to full-length ATF6 (p100) and processed N-terminal ATF6 (p50) are shown. The normalized p50/p100 ratio based on quantification of 5 experiments is shown. Data are shown as mean ± SEM. Nonparametric ANOVA, Kruskal-Wallis test (P = 0.0024) with Dunn’s multiple comparisons between selected groups were used. ** p < 0.01, R6/1 vs wt-DMSO, # p < 0.05, R6/1-RP vs R6/1-DMSO

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