Table 1 Gene expression studies of LMTK2 in neurodegeneration
From: Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration
Disease | Research model | Disease sample | Control sample | LMTK2 gene expression in disease sample | Statistical significance | Reference |
|---|---|---|---|---|---|---|
Alzheimer’s disease | Mouse tissue | Tau P301L cortex and hippocampus | Wild-type cortex and hippocampus | Decreased | Not known | [54] |
Parkinson’s disease | Human tissue | Substantia nigra | Substantia nigra from controls | Decreased | Not known | [107] |
Amyotrophic lateral sclerosis | Human embryonic stem cell-derived motor neuron | Neurons exposed to mutant SOD1 astrocyte conditioned medium | Non-treated neurons | Decreased | Not known | [108] |
Huntington’s disease | Mouse tissue | DE5 (D9-N171-98Q) striatum | Wild-type striatum | Decreased | Yes (p = 0,025) | [109] |