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Table 1 Gene expression studies of LMTK2 in neurodegeneration

From: Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration

Disease Research model Disease sample Control sample LMTK2 gene expression in disease sample Statistical significance Reference
Alzheimer’s disease Mouse tissue Tau P301L cortex and hippocampus Wild-type cortex and hippocampus Decreased Not known [54]
Parkinson’s disease Human tissue Substantia nigra Substantia nigra from controls Decreased Not known [107]
Amyotrophic lateral sclerosis Human embryonic stem cell-derived motor neuron Neurons exposed to mutant SOD1 astrocyte conditioned medium Non-treated neurons Decreased Not known [108]
Huntington’s disease Mouse tissue DE5 (D9-N171-98Q) striatum Wild-type striatum Decreased Yes (p = 0,025) [109]