Fig. 1

CTEP reduces surface but not total expression of mGluR5 in AD mice. a Representative western blots and mean ± SEM of mGluR5 surface expression b and total expression c in brain lysates from APPswe/PS1∆E9 (APPswe) and C57Bl/6 controls mice after chronic treatment with either saline or CTEP (2 mg/kg). d Representative western blots and mean ± SEM of mGluR5 surface expression e and total expression f in brain lysates from 3xTg-AD (3xTg) and B6129sf control mice after chronic treatment with either saline or CTEP. Values are expressed as a fraction of the saline-treated control. Surface expression represents quantification of biotinylated mGluR5 relative to total mGluR5 expression. Total mGluR5 expression was normalized to actin (n = 4–6 for each group). # Significantly different (P < 0.05) from corresponding C57B6/l or B6129sf values, * significantly different (P < 0.05) from saline-treated value