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Fig. 2 | Molecular Brain

Fig. 2

From: Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Fig. 2

ZBTB16-mediated activation of autophagy in AD mice is mGluR5-dependent. a Representative western blots and mean ± SEM of P62 and ZBTB16 in brain lysates from 3xTg-AD (3xTg) and control B6129sf mice after chronic treatment with either saline or CTEP (2 mg/kg). b Representative western blots and mean ± SEM of P62 and ZBTB16 in brain lysates from APPswe/PS1∆E9 (APPswe) and control C56Bl/6 mice after chronic treatment with either saline or CTEP or c genetic deletion of mGluR5 (mGluR5−/−). Representative Blots in panel from B and C are from the same blot. Values are expressed as a fraction of the saline-treated control. ZBTB16, and P62 are normalized to actin (n = 4 for each group). # Significantly different (P < 0.05) from corresponding control for each AD mouse model, * significantly different (P < 0.05) from saline-treated value. @ significantly different (P < 0.05) from saline treated C57Bl/6 or APPswe

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