Skip to main content

Advertisement

Fig. 3 | Molecular Brain

Fig. 3

From: Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Fig. 3

ULK1 activation plays a role in mGluR5-dependent activation of autophagy in AD mice. a Representative western blots and mean ± SEM of pULK-Ser757 in brain lysates from 3xTg-AD (3xTg) and control B6129sf mice after chronic treatment with either saline or CTEP (2 mg/kg). b Representative western blots and mean ± SEM of pULK-Ser757 in brain lysates from APPswe/PS1∆E9 (APPswe) and control C56Bl/6 mice after chronic treatment with either saline or CTEP or c genetic deletion of mGluR5 (mGluR5−/−). Representative Blots in panel from B and C are from the same blot. Values are expressed as a fraction of the saline-treated control. pULK-Ser757 is normalized to actin (n = 4 for each group). # Significantly different (P < 0.05) from corresponding control for each AD mouse model, * significantly different (P < 0.05) from saline-treated value. @ significantly different (P < 0.05) from saline treated C57Bl/6 or APPswe

Back to article page