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Fig. 8 | Molecular Brain

Fig. 8

From: Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Fig. 8

Contextual and cued fear conditioning test. a-f Effects of Rapgef2 deficiency. Conditioned stimulus (CS; 55 dB white noise for 30 s) and aversive unconditioned stimulus (UCS; 0.3 mA foot shock for 2 s) were given during the indicated periods. Percentages of freezing time during the conditioning phase (a), context testing and cued testing with altered context on day 2 (b), and context testing and cued testing with altered context performed 1 month after the last conditioning (c) were determined. Distance traveled in each time window of the conditioning phase was determined (d). Activity suppression ratios were determined for the context test (e) and cued test (f). g-l Effects of Rapgef6 deficiency. The tests examining the effects of Rapgef6 deficiency were performed as in a-f, and percentages of freezing time (g-i), distance traveled in the conditioning phase (j), and activity suppression ratios (k, l) were determined

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Molecular Brain

ISSN: 1756-6606