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Table 2 Comprehensive behavioral test battery of Rapgef2-cKO mice

From: Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Test

Age (w)

1. General health

17–23

2. Light/dark transition

17–24

3. Open field

18–24

4. Elevated plus-maze

18–24

5. Hot plate

19–25

6. Social Interaction (novel environment)

19–25

7. Rotarod

19–26

8. Social Interaction (Crawley version)

22–29

9. Prepulse inhibition

23–30

10. Porsolt forced swim

24–30

11. Barnes maze (training)

42–52

12. Barnes maze (probe test (24 h))

46–52

13. Barnes maze (probe test (1 month))

51–57

14. T-maze (forced alternation with fasting)

60–66

15. T-maze (left-right discrimination)

61–69

16. Tail suspension test

63–69

17. Fear conditioning test (Day 1)

63–70

18. Fear conditioning test (Day 2)

64–70

19. Fear conditioning test (Day 31)

68–74

20. Social Interaction (home cage)

69–76

21. Open field

72–78

  1. Age (w) age in weeks of mice at the beginning of each test listed