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Fig. 2 | Molecular Brain

Fig. 2

From: A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice

Fig. 2

Diet switch from NC to HFD acutely affected feeding behavior in mice. Mice were acclimated to FDAMS during NC feeding, then the diet was switched from NC to HFD60 (n = 6) for 10 days. White and black bars on the X-axis correspond to the light and dark cycles, respectively. Vertical dashed line indicates the switch from NC (Pre) to HFD and the initiation of IP injections (Post). (a) Hourly caloric intake over the course of the study (1 kcal = 4.186 kJ). (b) The light cycle intake, expressed as the percentage of the 24-h intake. (ce) Caloric intakes during (c) the light cycle, (d) the dark cycle, and (e) each 24-h period. (fh) Cosinor analyses of feeding rhythms, including the (f) period length, (g) amplitude, and (h) nadir of the CT. (i) Eatograms of representative mice. White and black bars above the traces correspond to the light and dark cycles, respectively. (j) Mean body weights. Data are the means ± s.e.m. Statistical significance was determined with the Student’s paired t-test, evaluated at each time point, for comparisons to the day before the diet switch (Pre, in be and day 0 in j). Significant differences were determined with a Student’s paired t-test for comparing data taken before and after the diet switch, in f-h. *P < 0.05. Abbreviations: NC normal chow, HFD high-fat diet, A.U. arbitrary unit, CT circadian time, FDAMS feeding drinking, and activity monitoring system

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