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Fig. 5 | Molecular Brain

Fig. 5

From: A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice

Fig. 5

INI-0602 did not affect feeding behavior or body weight in mice fed normal chow (NC). Mice were acclimated to FDAMS with NC feeding, then received intraperitoneal administration of vehicle (V, n = 5, white squares with dashed line) or INI-0602 (Tx, n = 5, black circles with solid line) every day for 10 days. White and black bars on the X-axis correspond to the light and dark cycles, respectively. Vertical dashed lines indicate the switch between no injection (Pre) and the initiation of IP injections (Post). (a-b) Hourly caloric intakes over the course of the study (1 kcal = 4.186 kJ) are shown for (a) the vehicle group and (b) the treatment group. (c) The light cycle intake, expressed as a percentage of the 24-h intake. (df) Mean daily caloric intakes during (d) the light cycle, (e) the dark cycle, and (f) each 24-h period. (gi) Cosinor analyses of the feeding rhythms, including the (g) period length, (h) amplitude, (i) and nadir of the CT. (j) Eatograms of two representative mice in each group. White and black bars above the traces correspond to the light and dark cycles, respectively. (k) Mean body weights. Data are the means ± s.e.m. Statistical significance was determined with the Student’s t-test, for comparisons between the two groups at each time point, in be and k. Significant differences were determined with a one-way ANOVA with the post-hoc Student’s t-test and the Bonferroni correction for comparisons among groups, in g-i. *P < 0.05. Abbreviations: NC normal chow, A.U. arbitrary unit, CT circadian time, IP intraperitoneal, FDAMS feeding drinking, and activity monitoring system

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