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Fig. 3 | Molecular Brain

Fig. 3

From: GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation

Fig. 3

Reduced GABAergic presynaptic components in the hippocampus of NL2 R215H KI mice. a Representative images of PV staining at the hippocampus in WT and R215H KI mice. Scale bar = 200 μm. b-d Quantification of PV-positive neurons at DG, CA2/3, and CA1 region. WT, n = 14 slices / 5 mice; KI, n = 14 slices / 5 mice. e Representative images of PV, vGAT and merged immunostaining in the granule cell layer of WT and R215H KI mice. f, g Quantification of PV puncta number and size that targeted to the granule cell layer. h, i Quantification of vGAT puncta number and size that targeted to the same region. WT = 12 slices / 5 mice, R215H KI = 12 slices / 5 mice. Scale bar = 10 μm. Student’s t test was used for analysis and data were shown as Mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001

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