Fig. 4

NL2 R215H KI mice have decreased inhibitory synaptic transmission at the hippocampal region. a, b Representative traces of miniature inhibitory postsynaptic currents (mIPSCs) recorded from DG granule cells in hippocampal slices of WT (black) and R215H KI (red) mice. WT, n = 14 cells / 4 mice; R215H KI, n = 18 cells / 4 mice. c, d Quantification of the mIPSC frequency and amplitude (Student’s t-test). e, f Representative traces of miniature excitatory postsynaptic currents (mEPSCs) in the DG region of hippocampal slices from WT (black) and R215H KI (red) mice. WT, n = 11 cells / 4 mice; KI, n = 12 cells / 3 mice. g, h Quantification of the mEPSC frequency and amplitude (Student’s t-test). Data represent mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001