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Fig. 5 | Molecular Brain

Fig. 5

From: NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation

Fig. 5

Expression and phosphorylation of ERK1/2 in the lumbar spinal cord dorsal horn. a & c The phosphorylation of ERK1/2 was increased in mice treated with 0.5 μg morphine (m) compared with that in the control group (n). Morphine-induced pERK1/2 expression was significantly decreased by 1 μg ketamine or 0.1 μg ifenprodil. b & d The phosphorylation of ERK1/2 was increased in mice treated with 0.5 μg morphine (m) compared with that in the control group (n) and the 0.1 μg (U1) and 1.0 μg (U2) U0126 groups. Morphine-induced pERK1/2 expression was significantly decreased by 0.1 μg (M+U1) or 1.0 μg (M+U2) U0126. There was no difference in the protein expression level of ERK1/2 among all groups. *: p<0.05, compared to the NS group, †: p<0.05, compared to the 0.5 μg morphine (M) group

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