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Fig. 6 | Molecular Brain

Fig. 6

From: NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation

Fig. 6

ERK1/2 phosphorylation inhibitor U0126 attenuated morphine-induced pruritus with no effect on its analgesia. a Morphine-induced pruritus (M 0.5 μg + DMSO) was obviously impaired by 0.1 μg or 1.0 μg U0126 in a dose-dependent manner. b U0126 (0.1 μg or 1.0 μg) significantly decreased the total number of scratches in 30 min that was induced by 0.5 μg morphine. c Time course of the effects of intrathecal morphine and intrathecal morphine + U0126 on morphine-induced analgesia during 2 h post-injection. %MPE showed no significant differences among the morphine group, morphine + 0.1 μg U0126 group and morphine + 1.0 μg U0126 group at 30, 60, 90 or 120 min post-injection. d The effect of U0126 on AUC calculated based on %MPE in (c). Compared with the AUC in the control group (NS + DMSO), the AUCs in the morphine group, morphine + 0.1 μg U0126 group and morphine + 1.0 μg U0126 group were all significantly increased. Error bars represent SEM. *: p<0.05, compared to the NS+DMSO group. †: p<0.05 compared to the 0.5 μg morphine + DMSO group

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