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Fig. 1 | Molecular Brain

Fig. 1

From: DNMT1 regulates expression of MHC class I in post-mitotic neurons

Fig. 1

Inhibitors of DNMT1 increase MHC-I gene expression in neuroblastoma cell lines. PCA dose-dependently increased HLA-A gene expression (a) and HLA-B gene expression (b) in human neuroblastoma cell line SK-N-AS. 5-aza dose-dependently increased the gene expression of H2-K1 (c), H2-D1 (d), and H2-D1/L (e) in mouse neuroblastoma cell line N2a. 72 h treatment with IFNγ (0,2 ng/uL in SK-N-AS and 0,5 ng/uL in N2a) significantly increases gene expression of HLA-A (a), HLA-B (b), H2-K1 (c) and H2-D1 (d). H2-D1/L gene expression was increased, but not significantly (p = 0.06) (e). Bars represent mean +/− S.E.M., N = 3. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. untreated in a One-Way ANOVA with Dunnett’s post hoc test

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