Fig. 3From: Chronic restraint stress induces hippocampal memory deficits by impairing insulin signalingImpairment of insulin signaling pathways and nesting behavior in mice subjected to chronic restraint stress (CRS). a Experimental scheme. b Body weight analyzed by two-way ANOVA (n = 11 per group). *p < 0.05, ***p < 0.001 (difference between days in the same groups); ###p < 0.001 (difference between Ctrl and CRS groups on the same days). c Concentration of blood CORT analyzed by unpaired t test (n = 6). d Nest building behavior assay. Representative results are shown. e Nest building scores analyzed by nonparametric Mann-Whitney U test (n = 11 per group). f Western blotting analysis of the insulin signaling pathway in the mouse hippocampus (n = 7 per group). g Quantification of insulin signaling molecules analyzed by unpaired t test. Data are mean ± SEM. *p < 0.05, ***p < 0.001Back to article page