Skip to main content
Fig. 2 | Molecular Brain

Fig. 2

From: Dysregulation of human NEFM and NEFH mRNA stability by ALS-linked miRNAs

Fig. 2

MiRNAs that have MREs in NEFM or NEFH 3’UTRs are down-regulated in the spinal cord of ALS patients. a MREs within NEFM and NEFH 3’UTRs of ALS-linked miRNAs. b Real-time PCR using SYBR green. Validation of differential expression in ALS versus control spinal cords of 6 miRNAs that have MREs in NEFM or NEFH mRNA 3’UTRs is shown. Experiments were performed in triplicate. Values below 1 indicate downregulation. Results are shown as mean ± SEM (Student t-test: **** p < 0.0001, *** p < 0.001, ** p < 0.01, * p < 0.05. MiR-9-5p, p = 0.0229; miR-20b-5p, p = 0.0230; miR-92a-3p, p = 0.0234; miR-125b-5p, p = 0.0412; miR-223-3p, p = 0.0215 and miR-519d-3p, p = 0.0232)

Back to article page