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Fig. 9 | Molecular Brain

Fig. 9

From: Stimulation-induced structural changes at the nucleus, endoplasmic reticulum and mitochondria of hippocampal neurons

Fig. 9

Images of the CA1 region of the hippocampus from a slice culture treated with 50 μM NMDA for 5 min (a), and from a delayed perfusion-fixed mouse brain (b, c). In addition to ER cisternal stacks (long small arrows), presence of CaMKII clusters (large arrows) and spinules (double arrows in b) indicates that these neurons are under heightened excitatory conditions. Furthermore, the thickness of PSD (short small arrows in a, b) is conspicuously greater than those of the control samples (inset of a is from a sister slice culture under control conditions; inset of b is from an age-matched mouse with fast perfusion-fixation). Mitochondria (m) appeared swollen in (a) but not in (b). Scale bar = 0.5 μm

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Molecular Brain

ISSN: 1756-6606