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Fig. 1 | Molecular Brain

Fig. 1

From: The effect of Neuroligin-2 absence on sleep architecture and electroencephalographic activity in mice

Fig. 1

Time spent (min ± SEM) in wakefulness, NREM sleep and REM sleep in Nlgn2+/+, Nlgn2+/− and Nlgn2−/− mice measured using EEG and EMG recordings. a) Total time spent in wake, NREM sleep and REM sleep for the total 24 h recording, the 12 h Light and the 12 h Dark periods. Significant genotype effects were found for 24 h wake (F2,37 = 4.8, p = 0.014), 24 h REM sleep (F2,37 = 16.9, p < 0.0001), 12 h Light REM sleep (F2,37 = 8.5, p < 0.001), 12 h Dark wake (F2,37 = 6.8, p = 0.003), 12 h Dark NREM sleep (F2,37 = 6.4, p = 0.004) and 12 h Dark REM sleep (F2,37 = 6.4, p = 0.004). No significant genotype effect was found for 24 h NREM sleep (F2,37 = 2.7, p = 0.08), 12 h Light wake (F2,37 = 1.3, p = 0.3) and 12 h Light NREM sleep (F2,37 = 1.1, p = 0.3). Stars show significant post-hoc Tukey HSD comparisons between indicated genotypes (*: p < 0.05; **: p < 0.01). b) Hourly distribution of wake, NREM sleep and REM sleep. For wakefulness, significant genotype and time effects were found (respectively, F2,37 = 4.8, p = 0.014 and F23,851 = 51.3, p < 0.0001), but no significant interaction was observed (F46,851 = 1.2, p = 0.14). For NREM sleep, a significant time effect was found (F23,851 = 47.0, p < 0.0001), but no significant genotype effect or interaction was observed (respectively, F2,37 = 2.7, p = 0.08 and F46,851 = 1.3, p = 0.07). For REM sleep, significant genotype and time effects were found (respectively, F2,37 = 16.9, p < 0.0001 and F23,851 = 52.3, p < 0.0001), but no significant interaction was observed (F46,851 = 0.8, p = 0.7). Grey backgrounds indicate the 12 h dark period

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