Fig. 5
Twenty-four hour time course of delta activity (1–4 Hz) during NREM sleep and theta activity (6–9 Hz) during wakefulness in Nlgn2+/+, Nlgn2+/− and Nlgn2−/− mice measured using EEG. a) 24 h dynamics of NREM sleep absolute delta activity (upper panel) and relative delta activity (lower panel). For absolute activity, significant genotype and interval effects have been found (respectively, F2,37 = 11.7, p < 0.001 and F17,629 = 38.0, p < 0.0001), as well as a tendency for significant interaction (F34,629 = 2.3, p = 0.05). For relative activity, a significant interaction has been observed (F34,629 = 3.4, p < 0.0001). Red symbols indicate intervals for which Nlgn2−/− mice are significantly different from Nlgn2+/+ mice, and dark red symbols indicate intervals for which Nlgn2+/− mice are significantly different from Nlgn2+/+ mice (simple effect analysis; p < 0.05). b) 24 h dynamics of waking absolute theta activity (upper panel) and relative theta activity (lower panel). For both absolute and relative activity, a significant interval effect was found (respectively, F17,612 = 3.6, p < 0.01 and F17,612 = 5.3, p < 0.0001), but no significant genotype effect (respectively, F2,36 = 2.2, p = 0.13 and F2,36 = 0.7, p = 0.5) or interaction (respectively, F34,612 = 1.2, p = 0.2 and F34,612 = 1.3, p = 0.13) was observed. Grey backgrounds indicate the 12 h dark period