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Fig. 3 | Molecular Brain

Fig. 3

From: Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor

Fig. 3

Anticonvulsant effects of CBD in a mouse model of seizures induced by NMDAR overactivation. a Behavioral alterations produced by the icv administration of 1 nmol NMDA to mice. Each bar indicates the percentage of mice showing the indicated sign and represents the mean ± SEM of 8 mice. b Effects of PPCC, CBD and BD1063 on seizures induced by NMDA. The mice received the NMDAR agonist NMDA icv (1 nmol) 30 min after the drugs (3 nmol PPCC, BD1063, CBD or 5 nmol WAY100635) and were then immediately evaluated. c Effect of the 5HT1AR antagonist WAY100635 on the convulsive syndrome evoked by 0.3 nmol NMDA. d Lack of an effect of CBD and BD1063 on seizures induced by 1 nmol NMDA in σ1R−/− mice. e Effects of the treatments on the latency and duration of the seizure episodes induced by 1 nmol NMDA in wild type and σ1R−/− mice. *Significant difference from the control group receiving NMDA and saline instead of the drugs. φ Significant difference from the corresponding NMDA-induced behavioral signs exhibited by the group receiving only CBD or BD1063, p < 0.05. ANOVA, Dunnett’s multiple comparison vs control group, p < 0.05

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Molecular Brain

ISSN: 1756-6606